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In vivo reports display anatomically selective neurochemical outcomes of modafinil on monoaminergic devices (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, though modafinil raises TMN fos expression (Scammell et al 2000) and HAergic tone it's not able to exert this impact when administered immediately to the TMN (Ishizuka et al 200